Week 16 NFL Picks: Detroit Lions vs. San Francisco 49ers

Week 16 of the NFL season resumes Sunday December 27th and a lot of bettors are focused on the Detroit Lions vs. San Francisco 49ers picks. Below you will see the Week 16 NFL Free Picks for the Detroit Lions vs. San Francisco 49ers game that will kickoff at 4:05 PM ET Sunday. The Oddsmakers currently have the Detroit Lions as 13 point underdogs at most top online sportsbooks.

Take the San Francisco 49ers -13, This pick falls into one of my top NFL systems and the 49ers are 5-0-2 ATS in their last 7 games after failing to cover the spread in their previous game. The 49ers are 6-1-1 ATS in their last 8 games after a loss and they are 16-7 ATS in their last 23 games when favored by -10.5 or more points. The Lions are just 6-19-1 ATS in their last 26 games after covering the spread in their previous game and they are just 1-5-1 ATS in their last 7 road games.

The 49ers have been playing great football at home having won 3 straight including dominating wins by more than 14 points against the Arizona Cardinals and Jacksonville Jaguars. The 49ers are 5-1 ATS in their last 6 home games against the Lions and I look or them to roll at home Sunday afternoon. Take the San Francisco 49ers as my NFL Free Play for Sunday December 27th.

Check out our Experts Week 16 NFL Picks between the Lions vs. Cardinals and come out on the winning side Sunday.

You May Also Like..:

1. NFL Week 12 Picks: New England Patriots vs. Detroit Lions Predictions
2. Chicago Bears vs. Detroit Lions NFL Picks Week 17
3. Arizona Cardinals-San Francisco 49ers Week 14 NFL Picks
4. NFL Week 8 Predictions: Denver Broncos vs San Francisco 49ers Odds
5. Chicago Bears vs. San Francisco 49ers NFL Week 10 Picks
6. Green Bay Packers vs. Detroit Lions Betting Picks & Odds
7. MNF Picks: San Francisco 49ers vs. Arizona Cardinals Predictions
8. Sunday Night Football Odds: Minnesota Vikings vs San Francisco 49ers Picks